Functions of MAO A and B
What are the functions of MAO A and B?
MAO A and MAO B degrade neurotransmitters in the body so that they are in the optimum concentration. This video shows the interaction between inhibitors or serotonin and MAO active sites — amino acids and cofactors (yellow colored) involved in the substrate and enzyme binding. As it rotates, the inhibitors become serotonin (the little black balls).
3-D Model by J. Ma and A. Ito (2004)
“Crystallization and preliminary crystallographic analysis of rat monoamine oxidase A complexed with clorgyline” (2004) J. Ma, F. Kubota, M. Yoshimura, E. Yamashita, A. Nakagawa, A. Ito and T. Tsukihara