In this video Dr. Shih describe MAO A deficiency and explains why MAO A-deficient mice fight and other behaviors that can be studied.
MAO B-deficient mice
When MAO B is absent, there will be a build up of phenylethylamine in the brain. There also will be increased reactivity to stress but little or no aggression in these mice. These mice are resistant to Parkinsonian inducing toxins (MPTP).
What happens to mice when they are both MAO A & B Deficient?
MAO A-deficient mice and aggression
In this video Dr. Shih describes the relationship between brain chemistry and aggressive behavior. Also she discusses:
• The next step
• Social factors and aggression
• Where these studies can lead
Two ways of treating aggressive behavior in mice
In this video, Dr. Chen describes two ways of treating aggressive behavior in mice: genetics and drugs.
FOREBRAIN SPECIFIC EXPRESSION OF MONOAMINE OXIDASE A REDUCES NEUROTRANSMITTER LEVELS, RESTORES THE BRAIN STRUCTURE AND RESCUES AGGRESSIVE BEHAVIOR IN MONOAMINE OXIDASE A DEFICIENT MICE, November 7, 2006
A comparison of MAO A knockout mice: the top frame shows aggressive mice and the bottom frame shows behavior modified with the drug tetrabenazine.