Biological evidence from mice to men



Jean Shih’s study with mice

In his pioneering study of a Dutch family with several generations of violent males, clinical geneticist Dr. Han Brunner has provided the first tangible evidence of a direct link between molecular biology (a MAO A deficiency) and aggressive behavior in humans.

• Dr. Brunner’s findings: distinctions in the family
• MAO A as a credible candidate
• Coming into contact with Dr. Shih

 

Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A, October 22, 1993

Link to article: 1993 Abnormal behavior in mutations for MAO A

 


Shih on the Brunner study

Dr. Jean Chen Shih, University Professor and Professor of Molecular Pharmacology and Toxicology at the USC School of Pharmacy

• The significance of Dr. Brunner’s work
• The biological component of behavior


Baker on the Brunner Study

Laura Baker, USC Professor of Psychology and Director of an extensive twin study, comments on the relevance of Brunner’s work to Dr. Shih’s studies and her own.

• The similarities between Dr. Shih’s work and Dr. Brunner’s work
• Dr. Baker’s study: a broader approach


Baker on Shih research

Laura Baker comments on the relevance of Brunner’s work to Dr. Shih’s studies and her own.

• Consistencies in the studies
• Differences