Mao Genes

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ARTICLES

2007

Forebrain specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure and rescues aggressive behavior in monoamine oxidase A deficient mice.

Journal of Biological Chemistry, volume 282, pages 115-223 (2007)

(Kevin Chen, Oliver Cases, Igor Rebrin, Weihua Wu, Timothy K. Gallaher, Isabelle Seif, and Jean Chen Shih)         

File: 2007 Forebrain-specific.pdf

2006

Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway.

Proceedings of the National Academy of Sciences, volume 103, pages 10923-10928 (2006)

(Xiao-Ming Ou, Kevin Chen, and Jean Chen Shih)         

File: 2006 MAO A and R1.pdf

2005

R1, a novel repressor of the human monoamine oxidase A.

Journal of Biological Chemistry, volume 280, 11552-11559 (2005)

(Kevin Chen, Xiao-Ming Ou, Gao Chen, Si Ho Choi, and Jean Chen Shih)

File: 2005 R1 Novel Repressor.pdf

Career Path – David T. Wong.

News & Analysis article in Nature Reviews Drug Discovery, volume 4, page 622 (August 2005)

File: 2005 David Wong_Nature.pdf

2004

Dual functions of transcription factors, transforming growth factor-_-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B Gene.

Journal of Biological Chemistry, volume 279, pages 21021-21028 (2004)

(Xiao-Ming Ou, Kevin Chen, and Jean Chen Shih)

File: 2004 Dual Functions.pdf

Serendipitous Double Knockout Sheds Light on Brain Chemistry,

an article in BioWorld Today on Jean Shih’s work

By Anette Breindl, Science Editor             

File: 2004 MAO double knockout.pdf

A spontaneous point mutation produces MAO A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior.

Journal of Biological Chemistry, Paper of the Week, volume 279, pages 39645-39652 (2004)

(Kevin Chen, Daniel P. Holschneider, Weihua Wu, Igor Rebrin, and Jean C. Shih)

File: 2004 ChenK Spontaneous.pdf

Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B

Neurotoxicity, volume 25, pages 21-30 (2004)

(Jean C. Shih)

File: 2004 Cloning After Cloning.pdf

2002

Role of genotype in the cycle of violence in maltreated children.Science, volume 297, pages 851-854 (2002)

(Avshalom Caspi, Joseph McClay, Terrie E. Moffitt, Jonathan Mill, Judy Martin, Ian W. Craig, Alan Taylor, Richie Poulton)

File 2002 caspi_moffit.pdf

Activation of Human Monoamine Oxidase B Gene Expression by a Protein Kinase C, MAPK Signal Transduction Pathway Involves c-Jun and Egr-1.

Journal of Biological Chemistry, volume 277, pages 22222-22230 (2002)

(Wai K. Wong, Xiao-Ming Ou, Kevin Chen, and Jean C. Shih)

File: 2002 Activation WKW.pdf

2001

Substrate and inhibitor specificities of human monoamine oxidase A and B are influenced by a single amino acid.

Journal of Biological Chemistry, volume 276, pages 9877-9882 (2001)

(Rani Maurice Geha, Igor Rebrin, Kevin Chen, and Jean Chen Shih)

File: 2001 Substrate Geha RM.pdf

1999

Shih JC, Chen K and Ridd MJ:  Role of MAO A and B in neurotransmitter metabolism and behavior. 

Polish Journal of Pharmacology, volume 51, pages 25-29 (1999)

File: 1999 MAO in Neuro.pdf

Monoamine oxidases: from genes to behavior.

Annual Review of Neuroscience, volume 22, pages 197-217 (1999)

(Jean C. Shih, Kevin Chen, and Michael J. Ridd M)

File: 1999 MAO Genes to Behavior.pdf

1997

Selective enhancement of emotional, but not motor, learning in monoamine oxidase A deficient mice.

Proceedings of the National Academy of Sciences USA, volume 94, pages 5929-5933 (1997)

(Jeansok J. Kim, Jean C. Shih, Kevin Chen, Lu Chen, Shaowen Bao, Stephen Maren, Stephan G. Anagnostaras, Michael S. Fanselow, Edward De Maeyer, Isabelle Seif, and Richard F. Thompson)

File: 1997 KimJJ-Selective.pdf

Increased stress response and _-phenylethylamine in MAOB-deficient mice.

Nature Genetics, volume 17, pages 206-210 (1997)

(Joseph Grimsby, Miklos Toth, Kevin Chen, Takeshi Kumazawa, Lori Klaidman, James D. Adams, Farouk Karoum, Judith Gal, and Jean C. Shih)

File: 1997 Increased stress.pdf

1995

Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAO A.

Science, volume 268, pages 1763-1766 (1995)

(Olivier Cases, Isabelle Seif, Joseph Grimsby, Patricia Gaspar, Kevin Chen, Sandrine Pournin, Ulrike Müller, Michel Aguet, Charles Babinet, Jean Chen Shih, and Edward De Maeyer)

File: 1995 CasesO Aggressive.pdf

1993

Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A.Science, volume 1993 262, pages 578-80 (1993)

(H. G. Brunner, M. Nelen, X.O. Breakefield, H.H. Ropers, and B.A. van Oost)

File: 1993 Brunner_AbBehavior.pdf

1991

Human monoamine oxidase A and B gene exhibit identical exon-intron organization.

Proceedings of the National Academy of Sciences USA, volume 88, pages 3637-3641 (1991)

(Joseph Grimsby, Kevin Chen, Li-Jia Wang, Nancy C. Lan, and Jean C. Shih)

File: 1991 Human MAO A B.pdf

1988

cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.

Proceedings of the National Academy of Sciences USA, volume 85, pages 4934-4938 (1988)

(Alfred W. J. Bach, Nancy C. Lan, Deborah L. Johnson, Creed w. Abell, Michael e. Bembenek, Sau-Wah Kwan, Peter H. Seeburg, and Jean Chen Shih)

File: 1988 cDNA cloning.pdf